What Everyone Needs to Know About Bipolar Disorder

Nine years ago, Julie Kraft’s doctor uttered the words, “you have bipolar II disorder.” Immediately, images of unhinged film characters, sensationalist tabloid headlines and shocking news stories flooded her mind. All these things are now associated with me, she thought. Kraft felt embarrassed, ashamed, sad—and afraid. “I was fearful of being judged, backed away from, viewed as unsafe, unpredictable, unstable, an unreliable friend, an irresponsible mom, a moody wife, a woman of weak character, and the list goes on and on.” It’s an understandable reaction because even though bipolar disorder is common—about 5.7 million American adults have it—myths and stereotypes still persist. To cut through the caricatures and misconceptions, we asked several individuals who have bipolar disorder and a clinician who specializes in treating the illness to share what they think everyone needs to know. Here’s what they said: Bipolar disorder is complex and varies from person to person. For starters, there are three types of bipolar disorder: bipolar I, bipolar II and cyclothymia. The hallmark symptom of bipolar I disorder is mania; many people also experience depression (but it’s not required for the diagnosis). Mania features hyperactivity, euphoria, disorganization, decreased need for sleep, impulsivity, impaired judgment, irritability, racing thoughts and speech, said Deborah Serani, PsyD, a psychologist in private practice i...
Source: Psych Central - Category: Psychiatry Authors: Tags: Bipolar Disorders Stigma Bipolar Disorder bipolar disorder myths bipolar disorder stereotypes bipolar I Bipolar Ii Cyclothymia Hypomania Mental Health Stigma Mood Disorders Source Type: news

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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Shi R, Wang C, Fu N, Liu L, Zhu D, Wei Z, Zhang H, Xing J, Wang Y Abstract Multiple drug resistance (MDR) and metastasis have been identified as the two major causes of the poor prognosis of patients with breast cancer. However, the relationship between MDR and metastasis has not been characterized. Epithelial‑mesenchymal transition (EMT), a process known to promote metastasis in cancer, has been shown to be associated with the MDR phenotype of many tumor types. Reduced cytokeratin 18 (CK18) expression is thought to be one of the hallmarks of EMT, and the role of CK18 in MDR of metastatic breast cancer r...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In conclusion, apoptin‑induced cell death may involve both autophagy and apoptosis. The induction of autophagy may inhibit apoptosis, whereas apoptosis may inhibit autophagy; however, occasionally both pathways operate at the same time and involve apoptin. This apoptin‑associated selection between tumor cell survival and death may provide a potential therapeutic strategy for breast cancer. PMID: 30896879 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Cheng Z, Shao X, Xu M, Wang J, Kuai X, Zhang L, Wu J, Zhou C, Mao J Abstract Colorectal carcinoma (CRC) is one of the most common malignancies worldwide and the second leading cause of cancer‑related deaths in the US. Recently, Rab1A has been reported to be an activator of mTORC1 and p‑S6K1, which is downstream of mTORC1. However, the association between Rab1A and p‑S6K1 in CRC remains elusive. In the present study, we first demonstrated that Rab1A was overexpressed in CRC tissues and Rab1A overexpression was positively related to lymph node invasion, degree of differentiation, venous invasion and tu...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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