Role of bone marrow adipocytes in leukemia and chemotherapy challenges.

Role of bone marrow adipocytes in leukemia and chemotherapy challenges.
Cell Mol Life Sci. 2019 Feb 04;:
Authors: Samimi A, Ghanavat M, Shahrabi S, Azizidoost S, Saki N
Abstract
Adipose tissue (AT) is an extramedullary reservoir of normal hematopoietic stem cells (HSCs). Adipocytes prevent the production of normal HSCs via secretion of inflammatory factors, and adipocyte-derived free fatty acids may contribute to the development and progression of leukemia via providing energy for leukemic cells. In addition, adipocytes are able to metabolize and inactivate therapeutic agents, reducing the concentrations of active drugs in adipocyte-rich microenvironments. The aim of this study was to detect the role of adipocytes in the progression and treatment of leukemia. Relevant literature was identified through a PubMed search (2000-2018) of English-language papers using the following terms: leukemia, adipocyte, leukemic stem cell, chemotherapy, and bone marrow. Findings suggest the striking interplay between leukemic cells and adipocytes to create a unique microenvironment supporting the metabolic demands and survival of leukemic cells. Based on these findings, targeting lipid metabolism of leukemic cells and adipocytes in combination with standard therapeutic agents might present novel treatment options.
PMID: 30715556 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - February 4, 2019 Category: Cytology Authors: Samimi A, Ghanavat M, Shahrabi S, Azizidoost S, Saki N Tags: Cell Mol Life Sci Source Type: research