Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy [Neuroscience]
Mutations in the MFN2 gene encoding Mitofusin 2 lead to the development of Charcot–Marie–Tooth type 2A (CMT2A), a dominant axonal form of peripheral neuropathy. Mitofusin 2 is localized at both the outer membrane of mitochondria and the endoplasmic reticulum and is particularly enriched at specialized contact regions known as mitochondria-associated...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Nathalie Bernard–Marissal, Gerben van Hameren, Manisha Juneȷa, Christophe Pellegrino, Lauri Louhivuori, Luca Bartesaghi, Cylia Rochat, Omar El Mansour, Jean–Jacques Medard, Marie Croisier, Catherine Maclachlan, Olivier Poirot, Per Uhlen Tags: PNAS Plus Source Type: research
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