RETRACTED: Analysis of gut microbiota in long-lived older adults and their relatives: a gradual change with ageing

Publication date: March 2019Source: Mechanisms of Ageing and Development, Volume 178Author(s): Qi Zhu, Linsheng Huang, Jian Zhu, Jianquan Lu, Huanlong QinAbstractPromoting the health span and lifespan of humans is the ultimate proposition of medical science. Several lifespan-reducing chronic diseases are associated with alterations in the gut microbiota (GM) composition. We aimed to identify the particular age-related GM trajectory in older Chinese adults and investigated the characteristic gut bacterial taxa of long-lived Chinese individuals. Faecal samples from 375 older adults (centenarians or adults nearly 100 years old and their younger immediate relatives) from a longevity area in East China were analysed by 16S-rRNA sequencing. The GM in the extreme-aged older adult group differed from that in the younger older adult group. GM community richness and some particular bacterial taxa (e.g., Escherichia-Shigella, Alistipes and Parabacteroides) are positively associated with ageing, whereas some other bacterial taxa (e.g., Prevotella_9 and Faecalibacterium) are negatively associated with ageing. The GM community diversity is positively associated with ageing in those from 50–59 to 90–59 to 90–99 years old and negatively associated with ageing in those from 90–99 to 100–99 to 109 years old. Our results indicate that the GM composition of healthy older adults changed gradually with ageing. Certain bacterial taxa stand out as the most characteristic of long-lived Chin...
Source: Mechanisms of Ageing and Development - Category: Geriatrics Source Type: research