A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities.

A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities. J Inorg Biochem. 2019 Jan 28;193:130-132 Authors: Hu X, Wang H, Huang B, Li N, Hu K, Wu B, Xiao Z, Wei Y, Wu P Abstract A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents. PMID: 30711559 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research