A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities.
A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities.
J Inorg Biochem. 2019 Jan 28;193:130-132
Authors: Hu X, Wang H, Huang B, Li N, Hu K, Wu B, Xiao Z, Wei Y, Wu P
Abstract
A new strategy to construct polyoxovanadate hybrids incorporating amino acid esters in mild conditions was presented in this paper. These new hybrids were not only structurally determined by Single Crystal X-Ray diffraction, but also exhibited higher antitumor activities against laryngeal carcinoma, rhabdomyoma, and breast adenocarcinoma tumor cells compared with the traditional commercial medicine 5-fluorouracil. These results would provide a promising lead scaffold for further design and synthesis of potential anticancer agents.
PMID: 30711559 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Hu X, Wang H, Huang B, Li N, Hu K, Wu B, Xiao Z, Wei Y, Wu P Tags: J Inorg Biochem Source Type: research
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