Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy

Dengue-specific antibodies can cross-react to Zika virus. Brown et  al. demonstrate that dengue-specific antibodies can enhance Zika virus pathogenesis during pregnancy by increasing damage to the placenta. These findings suggest a possible mechanism for the recent increase in severe pregnancy outcomes after Zika virus infection in areas where dengue co-circulates .

Source: Immunity - February 5, 2019 Category: Allergy & Immunology Authors: Julia A. Brown, Gursewak Singh, Joshua A. Acklin, Silviana Lee, James E. Duehr, Anupa N. Chokola, Justin J. Frere, Kevin W. Hoffman, Gregory A. Foster, David Krysztof, Richard Cadagan, Adam R. Jacobs, Susan L. Stramer, Florian Krammer, Adolfo Garc ía-Sas Tags: Article Source Type: research