Hyoscine for clozapine-induced hypersalivation: a double-blind, randomized, placebo-controlled cross-over trial

This study aims to examine the efficacy of hyoscine (scopolamine) for clozapine-induced hypersalivation. Fourteen inpatients diagnosed with treatment-resistant schizophrenia, treated with clozapine and suffering from hypersalivation were randomized to receive hyoscine 0.3 mg and placebo daily for 4 weeks each in a randomized, double-blind, placebo-controlled cross-over trial. The primary outcome was improvement in the Toronto Nocturnal Hypersalivation Scale. The secondary outcomes were change in the mass of the pillowcase, anxiety, depression and quality of life. Hypersalivation improved significantly with hyoscine over placebo when measured by the Toronto Nocturnal Hypersalivation Scale (odds ratio=0.21, 95% confidence interval: 0.16–0.28, P
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: ORIGINAL ARTICLES Source Type: research

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Objective: To compare the effects of a high-fidelity simulator and conventional teaching model used during blood pressure measurement training on students’ self-confidence, self-efficacy and anxiety levels. Methods: A randomized controlled trial design was used. The study was conducted on 59 first-year nursing students of a university in Amasya, Turkey. ‘Self-Confidence Scale,’ ‘general Self-Efficacy Scale’ and ‘Beck Anxiety Scale’ were used to collect the data. A high-fidelity simulator used in blood pressure measurement training was applied to the experimental group, while t...
Source: Blood Pressure Monitoring - Category: Cardiology Tags: Clinical Methods and Pathophysiology Source Type: research
ConclusionsFindings suggest that social anxiety is associated with an initial delay in attention disengagement from social threat that resolves over the course of repeated exposures to such stimuli. Treatment implications are discussed.
Source: Journal of Behavior Therapy and Experimental Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 11 November 2019Source: Neuroscience LettersAuthor(s): Yuting Liu, Han Yin, Huan Ma, Xueju Yu, Guihao Liu, Lan Guo, Qingshan GengAbstractIndividuals with anxiety disorder often exhibit as imbalance in response to stressors.We sought to explore the relationship between physiological as well as psychological responses under acute mental stress and the severity of the disease.20 Generalized Anxiety Disorder(GAD) patients (14 males,mean age 46 ± 10 years) were confronted with the stroop test,during which salivary-α-amylase(sAA),salivary cortisol,and heart rate varia...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
In conclusion, we emphasize that it is of importance to work closely with the hospital administration to take measures and that necessary assistance is provided. PMID: 31709934 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Conclusion: The study shows that nearly half of the T2DM patients that exhibited low level of functional health literacy had low diabetes self-management.  Our findings also show that gender significantly affects diabetes self-management in which odds are a lot higher among females than males with diabetes self-management. This study underscores the importance of proper counselling and education about diabetes control on both patients and family members. PMID: 31707414 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Conclusions: The prevalence of illness anxiety disorder among Saudi medical students is comparable to similar recent studies. Student counseling programs highlighting coping techniques, especially during the early study years, should be implemented. PMID: 31707412 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
CONCLUSION: This study identified prior antibiotic exposure, recent surgery and the use of invasive procedures as significant risk factors for colonization or infection with CRE. Also, the need for public awareness, continuing education for healthcare professionals, optimum use of invasive devices, enhanced surveillance, and antimicrobial stewardship are highlighted here which can limit CRE transmission in healthcare facilities. PMID: 31707406 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Publication date: Available online 11 November 2019Source: Biosensors and BioelectronicsAuthor(s): Leixia Meng, Ke Xiao, Xiaohua Zhang, Cuicui Du, Jinhua ChenAbstractDNA methylation catalyzed by M.SssI methyltransferases (MTase) has important roles in gene expression and other cellular activities, and relates to some diseases, especially cancers. Therefore, it is important to develop a sensitive sensing platform for M.SssI MTase activity assay. Here, taking zeolitic imidazolate framework-8 (ZIF-8) polyhedra as the carriers of graphene quantum dots (GQDs), GQDs-embedded ZIF-8 polyhedra (denoted as GQDs@ZIF-8 polyhedra) were...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Exposure to nitrogen dioxide during childhood raises the risk of schizophrenia, independent of genetic liability, results of a large, population-based study in Denmark show.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news
Conclusion: Genetic associations of diseases considerably vary across populations which necessitates health-related genotyping efforts especially for so far understudied populations. SOM portrayal represents novel promising methods in population genetic research with special strength in visualization-based comparison of SNP data. Introduction Non-communicable polygenic diseases such as cancers, neurodegeneration, cardiovascular, and metabolic disorders have become the most prevalent type worldwide and account for the majority of death events in developed and transition economy countries (Habib and Saha, 2010; Benzi...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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