Efficacy and acceptability of antidepressants in patients with ischemic heart disease: systematic review and meta-analysis

To assess the efficacy and acceptability of antidepressants in adults with ischemic heart disease (IHD). We gathered all available randomized-controlled trials comparing antidepressants versus placebo or other antidepressants in adults with IHD. The primary outcome was depressive symptoms at the study endpoint, as measured by validated rating scales. We pooled data in a meta-analysis using a random-effects model. The confidence in the estimates (or certainty of the evidence) was assessed using the GRADE approach. Antidepressants appeared to be more effective than placebo in reducing depressive symptoms (11 comparisons; 1685 participants; standardized mean difference −0.71, 95% confidence interval: −1.11 to −0.30; GRADE quality: moderate). This result was confirmed in the subgroup of serotonin selective reuptake inhibitors, and for the single drugs sertraline and citalopram, with a greater magnitude of effect and a higher quality of evidence for the former. No differences between antidepressants and placebo emerged in terms of acceptability and tolerability, quality of life, mortality, and cardiovascular events. Only two small head-to-head studies were identified. Sertraline is a reasonable first-line choice in patients with IHD and depression, whereas the role of citalopram as the first-line agent should be reconsidered.
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: REVIEW ARTICLES Source Type: research

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Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Brain embargoed study Source Type: news
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Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
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Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
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Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
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Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
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Source: Journal of Psychiatric Practice - Category: Psychiatry Tags: Columns Source Type: research
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Source: Maturitas - Category: Primary Care Authors: Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Brain Dementia Drugs Source Type: news
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