A FRET-based ratiometric fluorescent probe for detection of intrinsically generated SO2 derivatives in mitochondria.

A FRET-based ratiometric fluorescent probe for detection of intrinsically generated SO2 derivatives in mitochondria. Anal Chim Acta. 2019 Apr 11;1053:148-154 Authors: Song G, Liu A, Jiang H, Ji R, Dong J, Ge Y Abstract A mitochondria-targeted ratiometric fluorescent probe based on hemicyanine and pyrido[1,2-a]benzimidazole was presented. It shows high sensitivity and selectivity toward SO2 in pure water. The limit of detection (LOD) was as low as 26.7 nM, which is superior to most reported probes. Most importantly, the probe was successfully used for fluorescence imaging of endogenous bisulfite in mitochondria in Glioma cells. PMID: 30712560 [PubMed - in process]
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research