SPECT, MRI together advance arrhythmia treatment

The combination of information from cardiac MRI and iodine-123 metaiodobenzylguanidine...Read more on AuntMinnie.comRelated Reading: Augmented reality primed for MR-guided cardiac ablation 3D virtual heart helps pinpoint irregular heartbeat Imaging modalities differ in assessing key heart metric New protocol enables faster, cheaper cardiac MRI scans ASNC releases new guidelines for SPECT MPI
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Authors: Zeng L, Zhang Z, Wang X, Tu S, Ye F Abstract BACKGROUND The aim of this study was to investigate the correlations of circadian rhythm disorder of blood pressure with arrhythmia and target organ damage in hypertensive patients. MATERIAL AND METHODS A total of 198 patients admitted and treated in our hospital from May 2018 to April 2019 were selected to receive 24-h ambulatory blood pressure monitoring. The nighttime blood pressure decrease rate is 0-10% in people with normal circadian rhythm of blood pressure. In the present study, we divided patients into a normal circadian rhythm group (normal circadian r...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Mayr F, Vieider C, Temml V, Stuppner H, Schuster D Abstract Interference with the hERG potassium ion channel may cause cardiac arrhythmia and can even lead to death. Over the last few decades, several drugs, already on the market, and many more investigational drugs in various development stages, have had to be discontinued because of their hERG-associated toxicity. To recognize potential hERG activity in the early stages of drug development, a wide array of computational tools, based on different principles, such as 3D QSAR, 2D and 3D similarity, and machine learning, have been developed and are reviewed ...
Source: Progress in the chemistry of organic natural products - Category: Chemistry Tags: Prog Chem Org Nat Prod Source Type: research
Publication date: Available online 7 October 2019Source: Pathology - Research and PracticeAuthor(s): Dominik Gross, Christina LaursAbstractThe Jewish pathologist Carl Julius Rothberger (1871–1945) is undoubtedly one of the most important representatives of his field. His studies on atrial fibrillation, the bundle branch block and arrhythmia perpetua in particular secured him a place in medical history. Rothberger also gave the name to an agar used to prove the neutral red reduction of salmonella (Rothberger-Scheffler agar).While Rothberger’s name is well known in pathology, his biography and his experiences of ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionsThese findings provided strong evidences that TGD intervention ameliorated interstitial fibrosis, myocyte hypertrophy and gap junction expression in the IBZ, attenuated left ventricular remodeling and dysfunction, and reduced vulnerability to tachyarrhythmia. TGD inhibited IBZ remodeling by its inhibition effect on myofibroblasts differentiation.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 16 October 2019Source: Canadian Journal of CardiologyAuthor(s): Sattler Katherine, El-Battrawy Ibrahim, Gietzen Thorsten, Kummer Marvin, Lang Siegfried, Zhou Xiao-bo, Behnes Michael, Borggrefe Martin, Akin IbrahimAbstractBackgroundCardiogenic shock (1) is a severe complication of myocardial infarction (MI) or of takotsubo syndrome. For both diseases, CS is related to a worse long term outcome. Outcome of CS has not been studied in a direct comparison of MI patients and TTS patients.Methods and ResultsMortality and cardiovascular complications were compared in patients presenting with CS b...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionThe IECF is simple, particularly at reoperations, in borderline patients and those needing concomitant intracardiac procedures. Early results are promising. These patients need constant surveillance.
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
The transient receptor potential ankyrin 1 (TRPA1) channel is a calcium-permeable nonselective cation channel in the plasma membrane that belongs to the transient receptor potential (TRP) channel superfamily. Recent studies have suggested that the TRPA1 channel plays an essential role in the development and progression of several cardiovascular conditions, such as atherosclerosis, heart failure, myocardial ischemia–reperfusion injury, myocardial fibrosis, arrhythmia, vasodilation, and hypertension. Activation of the TRPA1 channel has a protective effect against the development of atherosclerosis. Furthermore, TRPA1 c...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In this edition of the Journal, Li et al report on patients with dilated cardiomyopathy (DCM) and arrhythmias (DCM-A) compared with patients with DCM with no arrhythmias (DCM-NA), with the explicit intent to identify the genetic causes of arrhythmias in DCM.1 Using whole-exome sequencing and high-depth targeted next-generation sequencing followed by Sanger sequencing of all causative variants to eliminate false-positive results, eight specific DCM-A pedigrees and two separate cohorts of 1232 consecutive unrelated sporadic DCM-NA patients were studied (550 patients in discovery cohort, 682 patients in replication cohort).
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
AbstractAtrial fibrillation (AF) is common in patients with obesity and diabetes; the arrhythmia (if long ‐standing) is typically managed by rate‐control and anticoagulation. However, the coexistence of these two metabolic disorders complicates therapeutic options for rate‐control. The likely pathogenesis of AF in these patients is an expansion of epicardial adipose tissue, whose inflammation is t ransmitted to the left atrium causing electromechanical remodeling. However, this same process is also transmitted to the left ventricle, impairing its distensibility and its ability to tolerate volume, leading to heart fai...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: COMPREHENSIVE REVIEWS Source Type: research
ConclusionA FIRM ‐guided approach was not associated with a significant difference in freedom from AF when compared to conventional ablation. Termination of AF with ablation was not associated with increased freedom from AF. While AF termination using substrate‐based ablation may have mechanistic implications fo r understanding AF rotor physiology, its impact on clinical outcomes remains unclear.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
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