Effects of Captopril on Cardiovascular Reflexes and Respiratory Mechanisms in Rats Submitted to Monocrotaline-Induced Pulmonary Arterial Hypertension

Conclusions The present study demonstrates that MCT-induced PAH induces compensatory respiratory responses, dysautonomia, and baroreflex dysfunction and increases chemoreflex responses. The data also indicate that CPT was effective in reversing these cardio-respiratory disorders, suggesting that ACEi could be a potential therapeutic target for PAH.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research