The effect of muscarinic M3 receptor blockage in development of M2 macrophages in allergic inflammation

We have reported that muscarinic M3 receptor antagonist (tiotropium) inhibits the allergic airway inflammation in murine model of asthma. However, the mechanism is still unclear. The purpose of this study is to investigate the effect of muscarinic M3 receptor blockage in development of M2 macrophages in allergic inflammation.

Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Shin Ohta, Megumi Jinno, Akihiko Tanaka, Tomoki Uno, Yoshitaka Uchida, Ryo Manabe, Hitomi Ida, Naota Kuwahara, Yosuke Fukuda, Tomoyuki Kimura, Kukniaki Hirai, Yoshito Miyata, Munehiro Yamaguchi, Tetsuya Homma, Fumihiro Yamaguchi, Yoshio Watanabe, Shintaro Source Type: research