Cytotoxic Triterpenoids from the Bark of Chisocheton patens Blume (Meliaceae)

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Unang Supratman, Wiro Naibaho, Supriatno Salam, Rani Maharani, Ace Tatang Hidayat, Desi Harneti, Nurlelasari, Yoshihito ShionoAbstractFour new triterpenoids, namely, chisopaten A-D (1-4), were isolated from the n-hexane extract of the bark of Chisocheton patens Blume. The chemical structures of new compounds were elucidated on the basis of spectroscopic data interpretation. All isolated compounds were evaluated for their cytotoxic activity against MCF-7 breast cancer lines. Chisopaten A and C, showed strongest cytotoxicity activity with IC50 values of 4.01 ± 0.008 and 4.33 ± 0.009 μM, respectively.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research