Upregulation of miR ‐200a and miR‐204 in MPP+‐treated differentiated PC12 cells as a model of Parkinson’s disease

ConclusionThe first novel finding of the current study is altered expression of miR ‐200a and miR‐204 in differentiated PC12 cells in response to MPP+, suggesting that deregulation of them participate in MPP+ neurotoxicity mechanisms, possibly via affecting the expression ofSirt1 andBCL2 as potential targets.

Source: Molecular Genetics & Genomic Medicine - February 3, 2019 Category: Genetics & Stem Cells Authors: Maryam Talepoor Ardakani, Mahsa Rostamian Delavar, Masoud Baghi, Mohammad Hossein Nasr ‐Esfahani, Abbas Kiani‐Esfahani, Kamran Ghaedi Tags: ORIGINAL ARTICLE Source Type: research