Ziprasidone-loaded arabic gum modified montmorillonite-tailor-made pectin based gastroretentive composites.

Ziprasidone-loaded arabic gum modified montmorillonite-tailor-made pectin based gastroretentive composites.
Int J Biol Macromol. 2019 Jan 29;:
Authors: Bera H, Abbasi YF, Yoke FF, Seng PM, Kakoti BB, Ahmmed SKM, Bhatnagar P
Abstract
Novel diethanolamine-grafted high-methoxyl pectin (DGP)-arabic gum (AG) modified montmorillonite (MMT) composites were developed for intragastric ziprasidone HCl (ZIP) delivery by combining floating and mucoadhesion mechanisms. The ZIP-loaded clay-biopolymer matrices were accomplished by ionotropic gelation protocol utilizing zinc acetate in the presence or absence of covalent crosslinker, glutaraldehyde (GA). Various formulations exhibited excellent drug entrapment efficiency (DEE, %) and sustained drug release profiles, which were influenced by the polymer-blend (DGP:AG) ratios, reinforcing filler (MMT) existence and crosslinking procedure. The optimal composites (F-3) demonstrated DEE of 61% and Q8h of 52% with outstanding buoyancy, mucin adsorption ability and biodegradability. The release profile of F-3 was best fitted in the Korsmeyer-Peppas model with Fickian diffusion driven mechanism. The mucin adsorption to composites F-3 followed Freundlich isotherms. The molar mass between crosslinks of composites (F-3) calculated employing Flory-Rehner equation was increased with temperature. Moreover, the thermal, X-ray and infrared analyses confirmed a compatible environment of drug in the composites, excep...

Source: International Journal of Biological Macromolecules - January 29, 2019 Category: Biochemistry Authors: Bera H, Abbasi YF, Yoke FF, Seng PM, Kakoti BB, Ahmmed SKM, Bhatnagar P Tags: Int J Biol Macromol Source Type: research