Associations between single nucleotide polymorphisms and erythrocyte parameters in humans: a systematic literature review

Publication date: Available online 2 February 2019Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Tiffany C. Timmer, Michael W.T. Tanck, Elisabeth M.J. Huis in’ t Veld, Barbera Veldhuisen, Joost G. Daams, Wim L.A.M. de Kort, C. Ellen van der Schoot, Katja van den HurkAbstractIndividual variations in erythrocyte parameters are influenced by factors like sex, age, diet and season. Genetic variations have also been associated with erythrocyte parameters. The aim of this systematic review is to provide an overview of associations between single nucleotide polymorphisms (SNPs) and erythrocyte parameters in humans. A systematic review protocol was published at the international prospective register of systematic reviews (registration number CRD42016053052). Literature searches were conducted in Medline and Embase. Studies were included if: investigating a(n) causality/association/correlation; population-based; investigating a human population of Caucasian/mixed-ethnic descent; and written in English, Dutch or German. Study quality was assessed using the quality of genetic association studies tool. In total, 4,385 studies were screened on title/abstract and 194 studies were screened on full text. Inclusion criteria were met by 13 candidate gene studies (n = 126–49,488) and eight genome-wide association studies (GWASes, n = 1,664–116,666). One moderate and six good quality GWAS(s) identified 1,237 SNPs located in/near 241 genes. SNPs in/near ten genes w...
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research