The GH/IGF-1 system in critical illness

This article reviews the current knowlegde and clinical practice of the use of rhGh and IGF-1 in critically ill patients, with a special focus on the trauma and burns patient population. Highlights ► The GH and IGF-1 axis plays a pivotal role in critical illness. ► IGF-1 modulates hepatic acute phase response signal pathway. ► IGF-1 serum levels increase during critical illness and protease activity decreases. ► GH ameliorates hypermetabolism and catabolism, but mortality increase is associated. ► With adequate nutrition, anabolic therapy may still be appropriate in select groups.
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research