Design, synthesis, and cytotoxic activity of 3-aryl-N-hydroxy-2(sulfonamido)propanamides in HepG2, HT-1080, KB, and MCF-7 cells.

Design, synthesis, and cytotoxic activity of 3-aryl-N-hydroxy-2(sulfonamido)propanamides in HepG2, HT-1080, KB, and MCF-7 cells. Chem Biodivers. 2019 Feb 01;: Authors: Shao DY, Zhang GN, Niu W, Zhu M, Wang J, Li D, Wang Y, Li ZQ Abstract A new series of compounds containing (sulfonamido) propanamide (6a1-13, 6b1-15, 7c1-5, 6d1-5, 6e1-6) was designed and synthesized. All the synthesized compounds were characterized by NMR and mass spectrometry. The target compounds were evaluated for their in vitro cytotoxic activity against hepatocellular carcinoma (HepG2), fibrosarcoma (HT-1080), mouth epidermal carcinoma (KB), and breast adenocarcinoma (MCF-7) cells with the sulforhodamine B (SRB) assay, with gemcitabine and mitomycin C as positive controls. Most of these compounds exhibit a more potent cytotoxic effect than the positive control group on various cancer cell lines and the most potent compound, 6a7, shows the IC50 values of 29.78 ± 0.516 μM, 30.70 ± 0.61 μM, and 64.89 ± 3.09 μM in HepG2, HT-1080, KB, and MCF-7 cells, respectively. Thus, these compounds with potent cytotoxic activity have potential for development as new chemotherapy agents. Keywords: Sulfonamido; Cytotoxic; Synthesis; SRB Assay. PMID: 30706997 [PubMed - as supplied by publisher]
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research