JAK/STAT inhibitors for the treatment of atopic dermatitis.

DISCUSSION: JAK inhibitors will most certainly be the first oral targeted option when topical therapy fails. With good oral bioavailability and lack of immunogenicity, they address some of the limitations of biologics. Yet to be defined is whether selective JAK 1 inhibitors or non-selective JAK inhibitors will provide the best equilibrium of efficacy versus side effects. Less clear is the position in the therapeutic ladder for topical JAK inhibitors, although an unmeet need exists in the topical treatment of AD. PMID: 30703333 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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ConclusionsThese results suggest possible association of these efflux transporters with dermal inflammatory mediators, and such association could be observed in the dermatitis skin.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research
In this study, we investigated the relation between TRPV3 and warmth-evoked itch in AD. Here, we found a marked upregulation of TRPV3 in AD-lesional skin compared with healthy skin or lesional skin of psoriasis or allergic contact dermatitis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Epidermal Structure and Function Source Type: research
In this study we investigate the long-term application of IMQ in this localized model.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research
We examined 16 patients: 6 with AD and 10 with PV. Every patient was examined and medical history was taken. Subsequently photography, thermography and high frequency ultrasound (33 MHz and 75 MHz) of skin lesions were performed.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Despite recent advances in understanding microbial diversity in skin homeostasis, the relevance of microbial dysbiosis in inflammatory disease is poorly understood. Here we characterized skin microbial communities coupled to the global pattern of cutaneous gene expression. Patients with atopic dermatitis (AD, n=82) or psoriasis (PSO, n=119) lesions were recruited to the study and sampled for the skin microbiota and skin transcriptome. The skin microbiota was analysed by 16S rRNA gene and whole genome sequencing, and the skin transcriptome by DNA microarrays, followed by exploratory analysis and integration of the data layers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Chronic skin diseases have significant impacts on the quality of life (QoL) of the patients, although not life threatening. However, current QoL measurements often do not adequately reflect the actual disease burden of the affected person. Willingness-to-pay (WTP) questionnaire was developed to assess disease burden economically. In this pilot study, we evaluated QoL and WTP in patients with five chronic skin diseases; alopecia areata (AA), atopic dermatitis (AD), chronic urticaria (CU), psoriasis, and vitiligo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory dermatitis treated with topical glucocorticoids (GC). Although long-term use of topical GC may induce skin atrophy including striae distensa (SD), AD patients appear to cause less skin atrophy compared to psoriasis. Chronic AD lesions are characterized by eosinophil infiltration and dermal fibrosis. Periostin, encoded by POSTN gene, augments TGF- β production in eosinophils and inversely activated eosinophils can induce periostin production in fibroblasts.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research and Epidemiology Source Type: research
Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease that is known to be, at least in part, genetically determined. Mutations in caspase recruitment domain-containing protein 14 (CARD14) have been shown to result in various forms of psoriasis and pityriasis rubra pilaris. In this research project, we aimed to identify rare DNA variants conferring a significant risk for AD through genetic and functional studies in a cohort of patients affected with severe AD. Whole exome and direct gene sequencing revealed in 4 patients from three families, 2 rare heterozygous missense mutations in the gene encodin...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity and Inflammation Source Type: research
ULK1 is strongly linked to autophagy, proliferation, apoptosis and inflammation. Keratinocytes in psoriasis is characterized by excessive proliferation, reduced apoptosis, altered differentiation and increased cytokine secretion. The role of ULK1 in psoriasis has not yet been elucidated. Therefore, the aim of our work was to clarify the expression pattern of ULK1 in psoriatic lesions and its role in the pathogenesis of psoriasis. We found that the epidermal expression of ULK1 protein and its active form of p-ULK1 was significantly lower in psoriasis patients than in healthy controls.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research
Mucosal associated invariant T (MAIT) cells are innate like lymphocytes found in peripheral blood and mucosa; they are decreased during systemic lupus erythematosus and other auto-immune diseases. However, MAIT cell levels and functions have not previously been investigated in dermatomyositis (DM). Herein, we studied MAIT cells level and activation status before and after treatment during DM (n=21) and compared them to healthy controls (n=19), psoriasis (n=7) and atopic dermatitis (n=5). We showed that DM was associated with a dramatic reduced number of circulating MAIT cells (median: 0.12% [0.073-0.25%] versus 2.13% [1.05-3.94%], p
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Adaptive Immunity and Autoimmunity Source Type: research
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