High-Intensity Interval Training in Patients with Type 2 Diabetes Mellitus: a Systematic Review
AbstractPurpose of ReviewHigh-intensity exercise may beneficially impact on insulin sensitivity. However, there is still uncertainty on the actual impact of high-intensity interval training (HIIT) on chronic physiologic adaptations among patients with type 2 diabetes mellitus (T2DM). We aimed to systematically search and appraise the evidence base on the effects of HIIT in comparison to mild- or moderate-intensity interval training (MMIIT) on glycemic control inT2DM.Recent FindingsA total of 5 RCT met the inclusion criteria. Most studies presented significant differences for weight and BMI with HIIT, and with both interventions for total body fat. For the other health-related variables (systolic and diastolic BP, fasting cholesterol, LDL and HDL, triglycerides, fasting glucose, and HbAc1), only 1 study provided detailed results for HIIT, showing significant differences for systolic BP and HDL cholesterol in 2 studies, total cholesterol, LDL, and triglycerides, whereas for MIIT, only 1 study brought significant differences for LDL cholesterol. For glucose levels, significant differences were reported in 4 studies for both HIIT and MMIT, but only two studies used the percentage delta assessment tool, whereas 1 study only showed significant improvements for HIIT.SummaryThe number of studies for the analysis is not precise as to the statements regarding the results of the intervention proposed for this public, since they do not allow identifying a consistency of the findings, not...
CONCLUSION: ATV inhibited ROS generation and activated IL-1 β/IL-6 secretion in PBMNC of diabetes patients. Its effect was not affected by the hyperglymemia. PMID: 31416412 [PubMed - as supplied by publisher]
Abstract Non-Alcoholic Fatty Liver Disease (NAFLD), the most common liver disease, is characterized by accumulation of fat (>5% of the liver tissue), in the absence of alcohol abuse or other chronic liver diseases. Its prevalence is increasing because of obesity, metabolic syndrome or Type 2 Diabetes Mellitus (T2DM). NAFLD can cause liver inflammation and progress to Non-Alcoholic Steatohepatitis (NASH), fibrosis, cirrhosis or Hepatocellular Cancer (HCC). Nevertheless, Cardiovascular Disease (CVD) is the most common cause of morbidity and mortality in NAFLD/NASH patients. Current guidelines suggest the use of p...
AbstractA direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high ‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, v asodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affe...
ConclusionOur nomogram can be used as a simple, plausible, affordable, and widely implementable tool to predict a personalized risk of T2DM for Central Chinese residents. The successful identification of at-risk individuals and intervention at an early stage can provide advanced strategies from a predictive, preventive, and personalized medicine perspective.
Background and Aims: Type-2 diabetes mellitus (T2DM) and metabolic syndrome (MS) are multifactorial and multigenic diseases and hallmarks for atherosclerosis and stroke. Characteristics of these diseases include glucose intolerance, insulin resistance, hypertension, and disorders in triglyceride and cholesterol metabolism. Despite intensive research in this area, major factors liable for T2DM and MS and in turn for treatment are still elusive.
Background and Aims: The aim of study is to evaluate the effect of statin on endothelial dysfuncion (ED) and soluble endoglin as an indicator of vascular injury and ED in type 2 diabetes mellitus (DM2) and hypercholesterolemia (H).
Background and Aims: To study the influence of middle-dose statin therapy on endothelial function in the combined course of arterial hypertension (AH), type 2 diabetes mellitus (DM2T) and subclinical hypothyroidism (SH).
Background and Aims:Diabetes, affecting more than 4% of Western population. Cardiovascular disease (CVD) is one of the most important complications and the major cause of death in diabetic patients . Elevated LDL and high triglyceride levels have been a major concern between CVD risk factors. Studies suggest that high triglyceride levels are commonly found in patients with diabetes mellitus type 2 (T2DM) . The aim of this study was to evaluate cardiovascular risk factors in a T2DM population with regulates LDL –cholesterol levels and hypertriglyceridemia
Background and Aims: Cholesterol efflux capacity (CEC) is a key metric representing HDL function which has a significant impact on atherosclerosis. We aimed to study the relationship between CEC and vascular function, inflammation and oxidative stress in Type 2 Diabetes Mellitus (T2DM).
Background and Aims: Dyslipidemia is a strong predictor for cardiovascular diseases and its prevalence is rising rapidly worldwide. Saroglitazar (Lipaglyn ®; Zydus Cadila, Ahmedabad, India), a novel dual peroxisome proliferator activated receptor agonist, is approved in India for management of diabetic dyslipidemia and hypertriglyceridemia in type 2 diabetes mellitus not controlled by statin alone. To evaluate the effect of saroglitazar in dyslipidem ia, this 24-week clinical trial was conducted from December-2014 to October-2017 in India.