Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.

CONCLUSIONS: In conclusion, in the left ventricles of aged mice the growth of capillaries and arterioles supplying cardiomyocytes were in proportion to whole organ hypertrophy. Spermidine had no effect on quantitative characteristics of capillaries or arterioles, suggesting that the beneficial effects of spermidine on the ageing heart do not depend on the quantitative structural characteristics of the microcirculation which does not exclude potential functional differences between the groups.
PMID: 30703435 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - January 28, 2019 Category: Geriatrics Authors: Wierich MC, Schipke J, Brandenberger C, Abdellatif M, Eisenberg T, Madeo F, Sedej S, Mühlfeld C Tags: Exp Gerontol Source Type: research