Role of the Purkinje system in Heritable Arrhythmias

Much has been written about arrhythmias in structurally normal hearts. Here we have focused on rapid ventricular arrhythmias that occur in hearts where a pathogenic genetic variant has been found in families in which arrhythmias occur. We discuss these mutations in terms of their effect on cardiac cell electrical function and initiation of arrhythmias (see Supplement). In addition, we have focused on the Purkinje cell, their anatomic networks and molecular signatures as the sites of origin of arrhythmias.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research