Preclinical efficacy of an anti-methamphetamine vaccine using E6020 adjuvant.

CONCLUSIONS: Thus, this anti-MA vaccine formulated with E6020 demonstrated effective functional protection against behavioral disruptions induced by MA.
SCIENTIFIC SIGNIFICANCE: Together, anti-MA vaccine showing a promising improvement in the efficacy of the vaccine that could be an effective candidate vaccine for methamphetamine use disorder (MUD). Furthermore, combinations of adjuvants may be a tool to design vaccines for MA dependence in humans. (Am J Addict 2019;XX:1-8).
PMID: 30701618 [PubMed - as supplied by publisher]

Source: American Journal on Addictions - January 31, 2019 Category: Addiction Authors: Arora R, Haile CN, Kosten TA, Wu Y, Ramakrishnan M, Hawkins LD, Orson FM, Kosten TR Tags: Am J Addict Source Type: research