In vitro and in vivo activity of D-serine in combination with β-lactam antibiotics against methicillin-resistant Staphylococcus aureus

In conclusion, D-serine had synergistic activity in combination with β-lactams against MRSA strains both in vitro and in vivo. Considering the relatively good safety of D-serine alone or in combination with β-lactams, D-serine is worth following up as new anti-MRSA infection strategies.Graphical abstractIn this study, the authors found that D-Ser had synergistic activity with β-lactams (represented by oxacillin and meropenem) against MRSA strains both in vitro and in vivo, demonstrated by results in MIC determination/Checkerboard assay, Time–kill curve analysis, murine systemic infection model and neutropenic thigh infection model.
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research