Effects of oxycodone hydrochloride on immune function and biochemical indexes in puerperas undergoing cesarean section.

Effects of oxycodone hydrochloride on immune function and biochemical indexes in puerperas undergoing cesarean section. J Biol Regul Homeost Agents. 2019 Jan 29;33(1) Authors: Wang HJ, Ding JF, Yu YL, Zhu LJ, Ying ZM, Cao DH, Wang MC Abstract The aim of this study was to investigate the effect of oxycodone on the immune function and biochemical parameters in puerpera undergoing cesarean section. The puerperas undergoing cesarean section were randomly divided into two groups, namely, the oxycodone hydrochloride group (group A) and the morphine group (group B). After the operation, patient controlled intravenous analgesia (PCIA) was used for medication. The analgesic effects at different time points, after 1 h, 2 h, 6 h, 12h, 24 h and 48 h, were recorded. The score of the numerical rating scale (NRS) of uterine contraction pain was evaluated. At the same time, peripheral blood was taken at different time points after analgesia (immediately after surgery, then 24 h, 48 h and 72 h after surgery). Th1 and Th2 cell levels and biochemical parameters were determined. Compared with the morphine group, the Th1 cell level in the oxycodone hydrochloride group was significantly increased at 24 h and 48 h after surgery (P less than 0.05). Th2 level was significantly increased compared to that of morphine at 24 h, 48 h and 72 h after surgery (P less than 0.05). The alanine aminotransferase (ALT) level and aspartate aminotransferase (AST) level in t...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research