Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

Publication date: February 2019Source: Seminars in Cell & Developmental Biology, Volume 86Author(s): Solana Alculumbre, Salvatore Raieli, Caroline Hoffmann, Rabie Chelbi, François-Xavier Danlos, Vassili SoumelisAbstractPlasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both T cell activation or tolerance. In this review, we described pDC functions during immune responses and their implication in the clearance or pathogenicity of human diseases during infection, autoimmunity, allergy and cancer. We discuss recent advances in the field of pDC biology and their implication for future studies.
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research