Getting into shape: tissue tension drives oriented cell divisions during organogenesis

The shapes and architecture of the organs in the animal body develop through complex coordination of cell shape change, cell migration, and cell proliferation. Finegan et al (2019) use the simple model of the Drosophila ovary and elongation of each egg chamber to explore this process. They find that a gradient of myosin-driven tension exists along the axis of organ elongation and that this orients the division of the constituent cells. This and other recent work highlight how tissue-level tension plays a key role in regulating tissue architecture.

Source: EMBO Journal - February 1, 2019 Category: Molecular Biology Authors: Manning, L. A., Peifer, M. Tags: Cell Adhesion, Polarity & Cytoskeleton, Development & Differentiation News [amp ] Views Source Type: research