Plunging Temperatures a Threat to People With Alzheimer's

Title: Plunging Temperatures a Threat to People With Alzheimer'sCategory: Health NewsCreated: 1/30/2019 12:00:00 AMLast Editorial Review: 1/31/2019 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news

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In conclusion, hyperactivation was found in individuals who later progressed to dementia, confirming that it might represent an early biomarker to identify individuals in the prodromal phase of AD and that its understanding could contribute to elucidate the key brain mechanisms that precede dementia.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
In this study, we aimed to characterize and differentiate age- and APOE gene-specific hemodynamic changes to breath-hold and visual stimulation. A further aim was to study whether these responses were modulated by 3-day intake of nitrate, a nitric oxide (NO) source. The study was designed as a randomized, double-blinded, placebo-controlled crossover study, and the study cohort comprised 41 APOE e4 carriers (e3/e4 or e4/e4 genotype) and 40 non-carriers (e3/e3 genotype) aged 30–70 years at enrollment. The participants underwent two scanning sessions, each preceded by ingestion of sodium nitrate or sodium chloride (co...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 22 July 2019Source: NeuroImage: ClinicalAuthor(s): Leonie Beyer, Jonas Schnabel, Philipp Kazmierczak, Michael Ewers, Sonja Schönecker, Catharina Prix, Johanna Meyer-Wilmes, Marcus Unterrainer, Cihan Catak, Oliver Pogarell, Robert Perneczky, Nathalie L. Albert, Peter Bartenstein, Adrian Danek, Katharina Bürger, Johannes Levin, Axel Rominger, Matthias BrendelAbstractObjectivesMany predictive or influencing factors have emerged in investigations of the cognitive reserve model of patients with Alzheimer's disease (AD). For example, neuronal injury, which correlates with cognitive de...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Overview of novel multifunctional agents based on conjugates of γ-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease. Chem Biol Interact. 2019 Aug 01;308:224-234 Authors: Makhaeva GF, Shevtsova EF, Boltneva NP, Lushchekina SV, Kovaleva NV, Rudakova EV, Bachurin SO, Richardson RJ Abstract Alzheimer's disease (AD) is a multifactorial neurodegenerative process whose effective treatment will require drugs that can act simultaneously on multiple pathogenic targets. Here, we present an overview of our previous multitarget studies of ...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
GRAPH CONVOLUTIONAL NEURAL NETWORKS FOR ALZHEIMER'S DISEASE CLASSIFICATION. Proc IEEE Int Symp Biomed Imaging. 2019 Apr;2019:414-417 Authors: Song TA, Roy Chowdhury S, Yang F, Jacobs H, El Fakhri G, Li Q, Johnson K, Dutta J Abstract Graph convolutional neural networks (GCNNs) aim to extend the data representation and classification capabilities of convolutional neural networks, which are highly effective for signals defined on regular Euclidean domains, e.g. image and audio signals, to irregular, graph-structured data defined on non-Euclidean domains. Graph-theoretic tools that enable us to study the b...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
With the amyloid hypothesis in Alzheimer's disease resulting in hundreds of failed clinical trials, researchers are looking to other biomarkers to guide diagnosis and care.Medscape Neurology
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery Article Source Type: news
Condition:   Prodromal Alzheimer's Disease Interventions:   Other: Partnered Rhythmic Rehabilitation (PRR);   Other: Group walking (WALK) Sponsors:   Emory University;   National Institute on Aging (NIA) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 22 July 2019Source: NeuroImageAuthor(s): Nanbo Sun, Elizabeth C. Mormino, Jianzhong Chen, Mert R. Sabuncu, BT Thomas Yeo, Alzheimer's Disease Neuroimaging InitiativeAbstractIndividuals with Alzheimer's disease (AD) dementia exhibit significant heterogeneity across clinical symptoms, atrophy patterns, and spatial distribution of Tau deposition. Most previous studies of AD heterogeneity have focused on atypical clinical subtypes, defined subtypes with a single modality, or restricted their analyses to a priori brain regions and cognitive tests. Here, we considered a data-driven hierarchical...
Source: NeuroImage - Category: Neuroscience Source Type: research
In at least some portions of the brain, new neurons are created throughout life in a process called neurogenesis. This is vital to memory and learning, but declines with age. Faltering neurogenesis is arguably implicated in the development of some neurodegenerative conditions. As most of the evidence for neurogenesis in adult individuals has been established in mice, and in recent years there has been some debate over whether or not these same processes do in fact operate in humans. So far, the most recent evidence leans towards supporting the existence of human adult neurogenesis. Given this, the research community remain...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(Alzheimer's Association) The Alzheimer's Association has awarded Longeveron LLC, a Miami-based biopharmaceutical company that develops cellular therapies for aging-related diseases, a $3 million grant to be applied to the company's mesenchymal stem cell Alzheimer's research.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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