Pharmacotherapeutic strategies for treating binge eating disorder. Evidence from clinical trials and implications for clinical practice.

Pharmacotherapeutic strategies for treating binge eating disorder. Evidence from clinical trials and implications for clinical practice. Expert Opin Pharmacother. 2019 Jan 29;:1-12 Authors: Amodeo G, Cuomo A, Bolognesi S, Goracci A, Trusso MA, Piccinni A, Neal SM, Baldini I, Federico E, Taddeucci C, Fagiolini A Abstract INTRODUCTION: Binge eating disorder (BED) is the most common eating disorder and was newly recognized in 2013 in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). BED is frequently associated with obesity and the metabolic syndrome, as well as with other psychiatric diseases, such as mood (49%), anxiety (41%), and substance use (22%) disorders. BED is highly prevalent and carries a high burden of mental and physical illness and disability. However, BED is frequently under-recognized and under-treated. Areas covered: This paper reviews the main pharmacological treatments for BED and provides an expert opinion based on the available evidence and on the authors' clinical experience with patients affected by BED. Expert opinion: Several medications have proven to be effective for the treatment of BED, including Lisdexamfetamine (LDX), topiramate as well as anti-anxiety and antidepressant medications. To date, LDX is the only FDA approved medication for BED. Consequently, as a general rule, the use of an FDA approved medication should always be preferred. However, when in the presence of concomitant psychia...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening hypoglycemia during starvation-like conditions, but do not consistently exhibit overt metabolic phenotypes when given ad libitum food access. These results, and findings of ghrelin resistance in obese states, imply nutritional state dependence of ghrelin’s metabolic actions. Here, we hypothesized that liver-enriched antimicrobial peptide-2 (LEAP2), a recently characterized endogenous GHSR antagonist, blunts ghrelin action during obese states and pos...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Ghrelin is a key signal driving energy seeking and storage in order to reverse energy deficit. In line with this view, the metabolic status of an organism predicts sensitivity to ghrelin, with fasting increasing and obesity decreasing ghrelin sensitivity, respectively. However, the mechanism responsible for controlling this sensitivity is unknown. In this issue of the JCI, Mani and colleagues show that plasma levels of plasma liver-enriched antimicrobial peptide-2 (LEAP2), a recently identified hormone that antagonizes the ghrelin receptor, are inversely correlated with those of plasma acyl-ghrelin under conditions of both...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In a society where physical activity is limited and food supply is abundant, metabolic diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster of metabolically related symptoms such as obesity, hypertension, dyslipidemia, and carbohydrate intolerance, and significantly increases type 2 diabetes mellitus risk. Insulin resistance and hyperinsulinemia are consistent characteristics of MetS, but which of these features is the initiating insult is still widely debated. Regardless, both of these conditions trigger adverse responses from the pancreatic β cell, which is responsible for produci...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 19 August 2019Source: Aggression and Violent BehaviorAuthor(s): Laura A. Andrews, Shannon L. Brothers, Jennifer S. Sauvé, Douglas W. Nangle, Cynthia A. Erdley, Melissa K. HordAbstractSomewhat surprisingly, social anxiety has been linked with aggressive behavior in adults. Among youth, this connection has been demonstrated with anxiety symptoms more broadly. This review extends previous work by evaluating this association specifically with social anxiety in the child and adolescent literature. Given the complexities of aggressive behavior, the review is organized by its various form...
Source: Aggression and Violent Behavior - Category: Psychiatry & Psychology Source Type: research
There is emerging evidence of a relationship between short sleep duration and poor quality of sleep with overweight and obesity. This has been clearly demonstrated in adults and there is increasing evidence of this relationship in children and adolescents. One area that needs more study is whether sleep patterns early in life are important for the development of subsequent obesity. This may be complicated because sleep in infants is more fragmented because it is interspersed with feedings. In this volume of The Journal, Tuohino et al report the results of their study that evaluated whether shorter sleep duration at 3 and 8...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research
ABSTRACT Aniridia is a congenital eye disorder with a variable degree of hypoplasia or absence of iris tissue. It is caused by loss of function of the PAX6 gene and may be an isolated ocular abnormality or part of a syndrome. WAGRO refers to a rare genetic condition leading to Wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity and is caused by a deletion of the short arm of chromosome 11 (11p), where the PAX6 gene is located. Here, we report on an 8-year-old boy with aniridia, polar cataract, and lens subluxation along with neuropsychomotor and speech delays. Karyotype evaluation showed an inte...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
Publication date: Available online 19 August 2019Source: Pregnancy HypertensionAuthor(s): Alfred O. Osoti, Stephanie T. Page, Barbra A. Richardson, Brandon L. Guthrie, John Kinuthia, Stephen J. Polyak, Carey FarquharAbstractObjectiveWe evaluated the 6-month postpartum risk of metabolic syndrome (MetS), a marker of future cardiovascular disease (CVD) risk, comparing women whose most recent pregnancies were complicated with gestational hypertension (GH) or preeclampsia (PE) versus those who had normotensive pregnancies.Study designThis was a prospective cohort study in which women with GH or PE and normotensive women were ac...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusion Auricular acupuncture is a promising practice for the treatment of chronic back pain in adults.
Source: Revista da Escola de Enfermagem da USP - Category: Nursing Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Conclusion: Even though demyelinating disorders are rare in pediatric age group, one should be aware of this entity as early diagnosis and treatment improves outcome. Most common among them is ADEM.
Source: Journal of Pediatric Neurosciences - Category: Neuroscience Authors: Source Type: research
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