Rethinking Glucagon for Emergency Use and Beyond
New forms of glucagon allow a ready-to-use rescue pen, and later possibly easy ways to give small doses to boost blood sugar for people with diabetes.
Although control of chronic glycemia in the population with diabetes and end-stage renal disease (ESRD) has been extensively studied in recent years, the unique problems of short-term glycemic management in acutely ill patients undergoing dialysis have received little attention. Bally et al. evaluated the role of a “closed-loop” (glucose sensor/algorithm tablet device/insulin pump) system in a cohort of hospitalized patients with type 2 diabetes receiving hemodialysis. Compared with usual care, the intervention group had superior glycemic control without increased hypoglycemic events.
An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history of renal disease.
Authors: Carretero-Anibarro E, Hamud-Uedha M PMID: 31427152 [PubMed - as supplied by publisher]
CONCLUSIONS: Dapagliflozin, in subjects with DM2, produces a medium to long-term decrease in arterial stiffness. PMID: 31420083 [PubMed - as supplied by publisher]
The Wound Ischemia foot Infection (WIfI) classification has gained widespread acceptance in the vascular community as a method of categorizing disease severity in patients with chronic limb-threatening ischemia (CLTI). The original WIfI system is based on a Delphi consensus model, which relies on an iterative process of consensus amongst experts, but is not necessarily data driven. Twelve experts were selected in the formation of the initial WIfI model. The WIfI classification was initially developed in a cohort of CLTI patients not undergoing revascularization, but since then has been extrapolated to predict outcomes of m...
This study aimed to assess the impact of perioperative hemoglobin A1c (HbA1c) levels on short- and long-term results after LEB.
Macrophage (M ϕ) plasticity allows transition of Mϕs from an inflammatory to a reparative phenotype and is critical for wound healing. In pathologic conditions, such as type 2 diabetes (T2D), wounds fail to heal because of impaired resolution of inflammation. Although the mechanisms responsible for persistent T 2D inflammation are unknown, growing evidence indicates that the Toll-like receptor (TLR) 4 and saturated fatty acids (SFAs) drive Mϕ-mediated inflammation. Given the excess SFAs in T2D, we hypothesized that SFAs induce epigenetic alterations in wound Mϕs and drive Mϕ inflammation that impairs di abetic wound healing.
ConclusionBeside the improvements in the laboratory variables, the individualized FATmax training can also benefit daily physical capacity of older people with type 2 diabetes.
Publication date: September 2019Source: Trends in Endocrinology &Metabolism, Volume 30, Issue 9Author(s): Zhiyong ChengAutophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear FoxOs transactivate genes that control the formation of autophagosomes and their fusion with lysosomes. Independently of tra...
Publication date: September 2019Source: The Lancet Diabetes &Endocrinology, Volume 7, Issue 9Author(s): Emma Ahlqvist, Tiinamaija Tuomi, Leif Groop