AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stressAKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress, Published online: 31 January 2019; doi:10.1038/s41388-019-0724-7AKT inhibition impairs PCNA ubiquitylation and triggers synthetic lethality in homologous recombination-deficient cells submitted to replication stress

Source: Oncogene - January 31, 2019 Category: Cancer & Oncology Authors: Florencia Villafa ñez Iris Alejandra Garc ía Sofia Carbajosa Mar ía Florencia Pansa Sabrina Mansilla Mar ía Candelaria Llorens Virginia Angiolini Laura Guantay Heinz Jacobs Kevin P. Madauss Israel Gloger Vanesa Gottifredi Jose Luis Bocco Gaston Soria Source Type: research