Increasing Stroke Tied to Injectable Opioids, Endocarditis Increasing Stroke Tied to Injectable Opioids, Endocarditis

The dramatic increase over the last decade in US hospitalizations for stroke from injectable drug-related infective endocarditis coincides with the surge in opioid misuse, new research suggests.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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Publication date: June 2019Source: Archives of Cardiovascular Diseases Supplements, Volume 11, Issue 3Author(s): A. Farah, O. Ben Abdeljelil, W. Jomaa, A. Gana, K. Ben Hamda, F. MaatoukIntroductionDespite all improvements in diagnostic imaging modalities and therapeutic regimens, Infective endocarditis remains a lethal disease especially in children. Stroke is an uncommon complication of endocarditis in children but it is an important cause of acquired brain injury which is associated with a higher mortality rate.MethodThis was a prospective study that included all children diagnosed with infective endocarditis (IE) and ho...
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Objectives: To evaluate the safety of acute ischemic stroke (AIS) therapy in patients with infective endocarditis (IE) with intravenous thrombolysis (IVT) or endovascular therapy (EVT) such as mechanical thrombectomy. Methods: We conducted a retrospective study of patients who underwent AIS therapy with IVT or EVT at a tertiary referral center from 2013 to 2017, that were later diagnosed with acute IE as the causative mechanism. We then performed a systematic review of reports of acute ischemic reperfusion therapy in IE since 1995 for their success rates in terms of neurological outcome, and mortality, and their risk of he...
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
Publication date: Available online 10 May 2019Source: The Annals of Thoracic SurgeryAuthor(s): Ville Kytö, Monna E. Myllykangas, Jussi Sipilä, Teemu J. Niiranen, Päivi Rautava, Jarmo GunnAbstractBackgroundBiological prostheses are preferred for surgical aortic valve replacement (SAVR) in patients aged>70 years in clinical practice. We studied differences in long-term outcomes between SAVR patients aged>70 years who received mechanical and biological prosthetic valves.MethodsAll patients (excluding endocarditis) aged>70 years with isolated first-time SAVR (±coronary artery by-pass grafting) in...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Long-term outcomes with mechanical versus biological aortic valve prosthesis in patients>70 years. Ann Thorac Surg. 2019 May 10;: Authors: Kytö V, Myllykangas ME, Sipilä J, Niiranen TJ, Rautava P, Gunn J Abstract BACKGROUND: Biological prostheses are preferred for surgical aortic valve replacement (SAVR) in patients aged>70 years in clinical practice. We studied differences in long-term outcomes between SAVR patients aged>70 years who received mechanical and biological prosthetic valves. METHODS: All patients (excluding endocarditis) aged>70 years with isolated first-time SA...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
Discussion Until now, the main tool used for bacterial identification based on NGS of the 16S–23S rRNA encoding region was de novo assembly followed by BLASTN on NCBI database (Sabat et al., 2017), however, there was no evidence that it would be the most accurate and/or fastest method available. The de novo assembly and BLASTN is the only approach of the three that works at the contig level, and both the OTU clustering and mapping are performed at the read level. Using the NCBI database for these two last approaches would have resulted in odd results, since the NCBI database includes sequences that do not belong to ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
We report a case of an acute ischemic stroke treated by mechanical thrombectomy, with the histopathological analysis of the retrieved clot followed by the confirmation of fungal endocarditis. An extensive review of the literature has been proposed and three key points concerning the fungal endocarditis predisposing factors, the relation between thrombolysis and hemorrhagic risk and, finally, the importance of clot analysis have been discussed.
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
AbstractPurpose of ReviewThe purpose of this narrative review and update is to summarize the current knowledge and provide recent advances on the neurologic complications of infective endocarditis.Recent FindingsNeurological complications occur in about one-fourth of patients with infective endocarditis. Brain MRI represents a major tool for the identification of asymptomatic lesions, which occur in most of the patients with infective endocarditis. The usefulness of systematic brain imaging and the preferred treatment of patients with infective endocarditis and silent brain lesions remains uncertain. The basis of treatment...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
ConclusionPatients with non-surgically treated IE with a stroke during IE admission were at significant higher associated risk of subsequent stroke within the first year of follow-up as compared with patients without a stroke during IE admission. This risk difference was not evident beyond one year of discharge. These findings underline the need for identification of causes and mechanisms of recurrent strokes after IE to develop preventive means.
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionsPatients who survived IE had an 8× higher incidence of nursing home admission and a 4× higher incidence of initiation of domiciliary care than their counterparts from the matched population.
Source: Global Heart - Category: Cardiology Source Type: research
CONCLUSION: Detailed morphological and histopathological analysis of EVT-retrieved clots including Gram staining can assist in etiological classification of the clot. Understanding the composition of the clot may be of clinical value in early diagnostics and mapping treatment planning in IE. PMID: 30867075 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - Category: Neurology Authors: Tags: Can J Neurol Sci Source Type: research
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