Does theFMR1 gene affect IVF success?

Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y Maher, William G KearnsAbstractFMR1 CGG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide repeat length published between 2002 and December 2017. For women with CGG repeats in the normal (
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

Related Links:

ConclusionIn spite of lower ovarian reserve and thanks to an increased total dose of FSH,FMR1 premutated selected patients seem to have similar ovarian response as fully mutated patients. Neither the number of CGG repeats inFMR1 gene norFMR1 mutation status was good predictors of the number of retrieved oocytes.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
FXS is the most common inherited form of intellectual disability. Population screening studies have been conducted among American and Australian populations; however, large population ‐based studies have not been completed in China. In this work we present FXS screening results from more than 10,000 women of child bearing age from China. We first created and tested a standard panel that was comprised of normal, intermediate, premutation, and full mutation samples. We have deter mined the intermediate carrier frequency as 1/130 among Chinese women, and the premutation carrier frequency as 1/634 women among Chinese women. ...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionThese results support the expansion of FXS screening criteria in guidelines.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
Novel Contribution of Secreted Amyloid-β Precursor Protein to White Matter Brain Enlargement in Autism Spectrum Disorder Deborah K. Sokol1, Bryan Maloney2, Cara J. Westmark3 and Debomoy K. Lahiri2,4* 1Pediatrics Section, Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States2Indiana Alzheimers Disease Center, Department of Psychiatry, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States3Department of Neurology, University of Wisconsin, Madison, WI, United States4Department of Medical and Molecular Genetics, Indiana Un...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y Maher, William G KearnsAbstractFMR1 CCG trinucleotide repeat expansions are associated with Fragile X syndrome (full mutations) and primary ovarian insufficiency (premutation range); the effect of FMR1 on the success of fertility treatment is unclear. The effect of FMR1 CGG repeat lengths on IVF outcomes after ovarian stimulation was reviewed. PubMed was searched for studies on IVF-related outcomes reported by FMR1 trinucleotide rep...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Publication date: Available online 10 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Lisa M Pastore, Mindy S Christianson, Bailey McGuinness, Kamaria Cayton Vaught, Jacqueline Y. Maher, William G KearnsABSTRACTWhile it is well known that FMR1 CCG trinucleotide repeat expansions are associated with Fragile X Syndrome (full mutations) and primary ovarian insufficiency (premutation range), the effect of FMR1 on fertility treatment success is less clear. This paper reviews the impact of FMR1 CGG repeat lengths on in vitro fertilization (IVF) outcomes after controlled ovarian hyperstimulation has commenced. PubM...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
This study describes a PM allele carried by the mother decreasing to a normal sized allele in a male from a dichorionic diamniotic (DCDA) twin pregnancy, with the female twin inheriting FM (200–790 CGGs), PM (130 CGGs) and normal-sized (39 CGGs) alleles. Further evidence of instability of the maternal PM allele was shown by a male proband (older brother) mosaic for PM (CGG 78 and 150 CGGs) and FM (200–813 CGGs), and a high level of FMR1 promoter methylation, between 50 and 70%, in multiple tissues. The fully-retracted, normal-sized allele was identified by PCR CGG sizing in the male twin, with no eviden...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Case Report Source Type: research
CONCLUSIONS: The overall prevalence of pre-mutation and asymptomatic full-mutation carriers in the Chinese pregnant population was one in 883, detected by a new FMR1 polymerase chain reaction assay. PMID: 28253484 [PubMed - as supplied by publisher]
Source: Hong Kong Med J - Category: Journals (General) Authors: Tags: Hong Kong Med J Source Type: research
We report herein results of a study performed in the Balearic Islands which had the following goals: 1) Determine the proportion of pregnant or non-pregnant women planning pregnancy, who would choose to undergo a screening test for Fragile X Syndrome (FXS), if it is accompanied by the appropriate information; 2) Assess satisfaction and any increase in stress among women who participate in screening; 3) Collect epidemiological information about the incidence of the disease in our population; and 4) Collect demographic and health history data and assess participants ’ awareness of the disease. Screening was performed o...
Source: Journal of Genetic Counseling - Category: Genetics & Stem Cells Source Type: research
Authors: Wilson RD, De Bie I, Armour CM, Brown RN, Campagnolo C, Carroll JC, Okun N, Nelson T, Zwingerman R, Audibert F, Brock JA, Brown RN, Campagnolo C, Carroll JC, De Bie I, Johnson JA, Okun N, Pastruck M, Vallée-Pouliot K, Wilson RD, Zwingerman R, Armour C, Chitayat D, De Bie I, Fernandez S, Kim R, Lavoie J, Leonard N, Nelson T, Taylor S, Van Allen M, Van Karnebeek C Abstract OBJECTIVE: This guideline was written to update Canadian maternity care and reproductive healthcare providers on pre- and postconceptional reproductive carrier screening for women or couples who may be at risk of being carriers for ...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
More News: Fragile X Syndrome | Genetics | Ovaries | Pregnancy | Psychology | Reproduction Medicine | Study | Women