Prioritizing putative influential genes in cardiovascular disease susceptibility by applying tissue-specific Mendelian randomization

ConclusionsDisease susceptibility can be influenced by differential changes in tissue-specific gene expression and DNA methylation. The approach undertaken in our study can be used to elucidate mechanisms in disease, as well as helping prioritize putative causal genes at associated loci where multiple nearby genes may be co-regulated. Future studies which continue to uncover quantitative trait loci for molecular traits across various tissue and cell types will further improve our capability to understand and prevent disease.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research