Serum Concentrations of Vascular Endothelial Growth Factor, Stromal Cell-Derived Factor, Nitric Oxide and Endothelial DNA Proliferation in Development of Microvascular Pathology in Acute African Swine Fever
Publication date: February 2019Source: Journal of Comparative Pathology, Volume 167Author(s): M.R. Tatoyan, Z.R. Ter-Pogossyan, A.B. Semerjyan, V.S. Gevorgyan, N. Yu Karalyan, C.T. Sahakyan, G.L. Mkrtchyan, H.K. Gazaryan, H.R. Avagyan, Z.A. KaralyanSummaryThere is significant evidence that pathology of the microcirculation occurs in African swine fever (ASF); however, the mechanisms by which it develops are largely unknown. In the present experimental infection study, we show that an increase in vascular permeability in the initial stages of acute ASF is dependent on viraemia and elevation of the concentration of serum nitric oxide (NO). Macrophages activated by ASF virus (ASFV) are stimulated to produce NO and simultaneously to sensitize the endothelial cells through the action of vascular endothelial growth factor Β (VEGFΒ), which is followed by an increase in VEGF-mediated endothelial permeability. In the later stages of disease, the endothelial cells undergo DNA proliferation, which may additionally provoke capillary leakage, point haemorrhages and migration of blood cells into tissues. The possible mechanism of a shift in the cell cycle from the G1 to S and G2 stages could be a direct effect of ASFV. The terminal stages of disease are characterized by triggering of compensatory mechanisms such as stimulation of the synthesis of stromal cell-derived factor-1.
AM Abstract Adoptive transfer of T cells transgenic for tumor-reactive T-cell receptors (TCR) is an attractive immunotherapeutic approach. However, clinical translation is so far limited due to challenges in the identification of suitable target antigens as well as TCRs that are concurrent safe and efficient. Definition of key characteristics relevant for effective and specific tumor rejection is essential to improve current TCR-based adoptive T-cell immunotherapies. We here characterized in-depth two TCRs derived from the human leukocyte antigen (HLA)-mismatched allogeneic repertoire targeting two different myel...
ConclusionsThe study recommend the development of a model to guide the integration of breast cancer prevention and early detection into palliative care
This study describes the nurses’ perceptions of caring and uncaring nursing encounters in inpatient rehabilitation settings. Twenty-one nurses (enrolled and professional) participated in the study. Individual in-depth interviews were conducted. Data were analysed using qualitative content analysis to uncover the manifest content. Caring nursing encounters were “keeping their hope alive” and “going the extra mile”, while uncaring nursing encounters were “frustration with patients”, “not doing enough” and “ignoring”. Caring nursing encounters promoted positive...
ConclusionThe study revealed that professional nurses need effective support, mentoring and supervision throughout IMCI implementation by the Mother, Child and Women Health (MCWH) coordinators. Caregivers and mothers need to know the importance of providing a comprehensive child history to professional nurses and therefore they need to be encouraged to disclose all relevant information during the IMCI process.
This study aims to explore the types of ICT applications used and the skills level of nursing students at a selected university in South Africa.MethodsA non-experimental, descriptive quantitative research design was used in this study, and it was conducted at a selected university in South Africa. A total number of 150 nursing students participated in this study. Data were collected using a structured questionnaire and were analysed using SPSS version 25.FindingsThe majority of the respondents reported being skilled in using Word processing application (Ms Word) (86.7 %), Ms PowerPoint (70.7%), Moodle (81.3%), and online r...
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM01184F, PaperDong Wang, Xiaojun Hou, Xuecheng Zhang, Yurong Zhao, Yawei Sun, Jiqian Wang An injectable biomaterial has been prepared through co-assembly of lipopeptides C4-Bhc-Glu-Glu-NH2 and C14-Phe-Lys-Lys-NH2. This biomaterial contained a large number of nanofibre bundles (nano-bundles, NBs) of lipopeptide co-assemblies and performed like... The content of this RSS Feed (c) The Royal Society of Chemistry
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM00988D, PaperEduard Benet, Franck J. Vernerey The mechanics of blister delamination and growth plays a major role in a diversity of areas including medicine (skin pathology, echanics of cell membrane), materials (adhesive and fracture) or soft... The content of this RSS Feed (c) The Royal Society of Chemistry
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP02585E, PaperQiuShi Song, Zheng Zhang, Hongwei Xie, Huayi Yin, ZhiQiang Ning Carbonization of Nb has been systemically investigated in Ar atmosphere and molten salt. The carbonization of transitional metals was considered from thermodynamics and kinetics. Dynamic barriers for the formation of... The content of this RSS Feed (c) The Royal Society of Chemistry
This article is licensed under aCreative Commons Attribution-NonCommercial 3.0 Unported Licence.Justin Conrad, Shinae Kim, Mark Gordon The efficacy of using fragmentation methods, such as the effective fragment potential, the fragment molecular orbital and the effective fragment molecular orbital methods are discussed. The advantages and current limitations... The content of this RSS Feed (c) The Royal Society of Chemistry
Dalton Trans., 2019, Accepted Manuscript DOI: 10.1039/C9DT02472G, PaperLu Zhai, Jing −Wei Yu, Jin Zhang, Wen-Wei Zhang, lifeng Wang, Xiaoming Ren A multifunctional material, with two or more types of functionalities in a single material, might give new phenomena and novel applications. Metal −organic frameworks (MOFs) or porous coordination polymers (PCPs) can... The content of this RSS Feed (c) The Royal Society of Chemistry