Acute Traumatic Brain Injury Induces CD4 < sup > + < /sup > and CD8 < sup > + < /sup > T Cell Functional Impairment by Upregulating the Expression of PD-1 via the Activated Sympathetic Nervous System

Conclusion: Our findings demonstrated that aTBI activated the SNS, and further upregulated the expression of PD-1 on CD4+ and CD8+ T cells, which, in turn, impaired their function and contributed to immunosuppression.Neuroimmunomodulation
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research