Thrombotic Microangiopathy after Pediatric Allogeneic Stem Cell Transplant: Potential Early Markers to Predict Individuals at High-Risk
Transplant associated thrombotic microangiopathy (TMA) is a severe complication of stem cell transplant (SCT), characterized by endothelial damage leading to microangiopathic hemolytic anemia, thrombocytopenia and organ damage. Mild cases of TMA do not require treatment, but severe cases are associated with organ damage and mortality. Soluble suppression of tumorigenicity-2 (ST2) is a member of the interleukin 1 receptor family and has been associated with cardiac as well as endothelial injury. Elevated soluble terminal complement complex (sC5b-9) has recently been shown to be associated with high-risk TMA.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Christopher E Dandoy, Audrey Stegman, Abigail R Pate, Ava Stendahl, Priscila Badia Alonso, Sonata Jodele, Adam Lane, Stella M Davies Tags: 58 Source Type: research
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