Stabilization and Reversibility of Early Lung Abnormalities Post-HSCT Detected with Serial Hyperpolarized 129Xe MRI

Early detection of lung abnormalities following hematopoietic stem cell transplant (HSCT) remains a challenge primarily due to the insensitivity of spirometry, the current clinical gold standard, to mild changes. This insensitivity carries through to assessing treatment response and personalizing pulmonary interventions for HSCT patients. Hyperpolarized 129Xe magnetic resonance imaging (MRI) has been demonstrated to be sensitive to early regional airway obstruction, and as a modality free of ionizing radiation, we hypothesized that serial 129Xe MRI could gauge treatment response in pediatric HSCT patients.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 368 Source Type: research