Assessment of Safety and Efficacy of PBSC Mobilization with G-CSF and CD34+ Enrichment and Pbmnc (CD3+) Addback in Familial Haploidentical (FHI) Adult Donors with Sickle Cell Disease Trait (SCDT) Prior to Allogeneic HSCT of High-Risk SCD Patients

We and others have previously reported the safety of allogeneic stem cell transplantation in children with SCD without sibling HLA matched bone marrow donors who commonly have SCDT. The majority of the sibling donors donated bone marrow and received G-CSF mobilized PBSCs (Bhatia/Cairo et al, BMT 2014; Gluckman et al, Blood 2017). Furthermore, only 14-18% of siblings can serve as donors based on HLA match and presence of SCD (Mentzer, Am J Ped Hem/Onc 1994; Walters, BBMT 1996). Unrelated cord blood as a donor source for SCD patients was associated with unacceptable primary graft failure rates (Radhakrishnan/Cairo, BBMT 2013).

Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: Bronwyn Gillian Long, Allyson Flower, Sandra Fabricatore, Erin Morris, Harshini Mahanti, Qiuhu Shi, Carolyn A. Keever-Taylor, Rona S. Weinberg, Brenda Grossman, Julie-An M. Talano, Shalini Shenoy, Theodore B. Moore, Janet Ayello, Mildred Semidei-Pomales, Tags: 457 Source Type: research