Autologous Stem Cell Transplant for IgM Related AL Amyloidosis

IgM related AL amyloidosis is a rare disease with patients presenting with more renal and neurological involvement and less cardiac involvement compared to those with non-IgM related disease. We retrospectively reviewed 38 patients receiving autologous stem cell transplant (ASCT) for IgM related AL amyloidosis at the Mayo Clinic between May 1999 and June 2018. Median age was 61 years and 71% were male. The most common organs involved were renal (63%), neurological (32%) and cardiac (26%). The median difference between involved and uninvolved free light chains (dFLC) was 6.2 mg/dL and most patients had early mayo stage (87% Mayo Stage I 2004 and 74% Mayo Stage I 2012).

Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: M. Hasib Sidiqi, Francis Buadi, Angela Dispenzieri, Rahma Warsame, Martha Q. Lacy, David Dingli, Nelson Leung, Wilson I. Gonsalves, Prashant Kapoor, Taxiarchis Kourelis, William J. Hogan, Shaji Kumar, Morie Gertz Tags: 588 Source Type: research