Efficacy of Allogeneic Hematopoietic Cell Transplantation (HCT) in Primary Cutaneous T Cell Lymphoma: Results of a Systematic Review/Meta-Analysis

Mycosis Fungoides (MF) and S ézary Syndrome (SS) are the most common types of primary cutaneous T cell lymphomas. The clinical presentation of MF is generally indolent whereas SS represents a more aggressive variant. Stage at diagnosis is the most important determinant of long-term survival outcome. Although most patients pres ent with early stage, patients who develop progressive disease or have advance stage represent a therapeutic challenge owing to the lack of effective therapies. Allogeneic HCT has been used as a potentially curative treatment modality because autologous HCT, conventional chemotherapies and newer age nts have not resulted in long-term durable remissions.

Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: Madiha Iqbal, Tea Reljic, Taimur Sher, Ernesto Ayala, Hemant Murthy, Vivek Roy, James Foran, Han Tun, Ambuj Kumar, Mohamed A. Kharfan-Dabaja Tags: 599 Source Type: research