Post-Transplant Radiation Had No Impact on Survival in Patients with Refractory or Relapsed Diffuse Large B-Cell Lymphoma

High-dose chemotherapy followed by autologous hematopoietic cell transplantation (AHCT) offers cure for appropriate patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) sensitive to chemotherapy. Post-AHCT consolidative radiation therapy (RT) has been associated with improved outcomes in R/R DLBCL patients with bulky [based on computed tomography (CT)] disease after AHCT. We and others have demonstrated that patients with a Deauville score 4-5 (high-risk) on pre-AHCT FDG positron emission tomography (PET) have significantly worse outcomes as compared to those with Deauville 1-3 (low risk).

https://www.bbmt.org/article/S1083-8791(18)31758-0/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - January 31, 2019 Category: Hematology Authors: Dhruvika Mukhija, Malvi Savani, Sanah Shaikh, Sheetal Shah, Lisa Rybicki, Allison Winter, Deepa Jagadeesh, Aaron T. Gerds, Robert M. Dean, Christopher Wilke, Ronald M. Sobecks, Brad Pohlman, Brian Bolwell, Matt E. Kalaycio, Betty K. Hamilton, Navneet S. M Tags: 615 Source Type: research