Thymectomy + PDN Beneficial for Non-Thymomatous Myasthenia Gravis

WEDNESDAY, Jan. 30, 2019 -- For patients with non-thymomatous myasthenia gravis, thymectomy plus prednisone confers benefits versus prednisone alone at five years, according to a study published online Jan. 25 in The Lancet Neurology. Gil I. Wolfe,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Injectable immunoglobulins —often referred to as Intravenous Immunoglobulins (IVIg) despite the fact that intramuscular and subcutaneous Ig are available—were primarily designed to use to substitute primary immunodeficient (PID) patients [1]. Exogenous immunoglobulins (Igs) are indeed essential for immunodeficient patient s to cope with most current infections in addition to antibiotics [1]. Secondary immune deficiencies have further been acknowledged as legitimate indications for IVIg [2]. Finally, IVIg were prescribed, often in combination with therapeutic plasma exchange, in a number of autoimmune disorders;...
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Editorial Source Type: research
Paraneoplastic autoimmune multi-organ syndrome (PAMS) is a rare clinical condition characterized by variable and heterogeneous clinical phenotypes in the presence of neoplasias which largely depend on the activation of humoral and cellular immune responses. Clinically, these patients present with a spectrum of pemphigus-like lesions to graft-vs-host-disease-like exanthemas with a lichenoid inflammatory infiltrate in the skin. PAMS is occasionally associated with thymoma. We here present a patient with relapsing thymoma who developed PAMS with several cutaneous and extracutaneous autoimmune disorders. Peripheral blood lym...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Amifampridine tablets have receivedapproval for treating children aged 6 to 17 years who have Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disease that causes debilitating muscle weakness.
Source: JAMA - Category: General Medicine Source Type: research
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associate...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Case report Source Type: research
Autoimmune encephalitis (AE) is a newly recognized autoimmune disorders in which the targets are proteins or receptors involved in synaptic transmission and neuronal excitability. α-amino-3-hydroxy-5-methyl-4-...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
Authors: Jordan H, Ortiz N Abstract Myasthenia gravis is a neuroimmunological disorder leading to skeletal muscle weakness. Common symptoms of the disease, such as anxiety, depression, and insomnia, can cause significant distress in patients. Unfortunately, selecting an appropriate medication for treatment of psychiatric comorbidities can prove to be challenging for providers given the unique pharmacologic constraints that myasthenia gravis presents. The authors present the following clinical vignette and accompanying discussion in an attempt to highlight the special considerations that must be taken into account w...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
The thymus is a dynamic organ that undergoes changes throughout life and can demonstrate a myriad of pathologic alterations. A number of benign entities of the thymus prove to be diagnostic dilemmas owing to their resemblance and association with true thymic tumors. These are usually discovered incidentally on routine imaging and most patients are either asymptomatic or present with signs and symptoms of compression of adjacent organs. The radiologic appearance of these lesions varies from simple cysts to complex masses that are suspicious for malignancy. The diagnosis is usually made purely on morphologic grounds, however...
Source: Advances in Anatomic Pathology - Category: Pathology Tags: Review Articles Source Type: research
This study of MG patients compared the effect of early and late extubation following thymectomy on clinical outcome.MethodsWe performed a study of data from 96 patients with MG who received thymectomy procedures, followed by early (  6 h) extubation, at our institution between October 2011 and November 2017. Patient clinical and demographic characteristics, preoperative data, and postoperative clinical outcomes were analyzed. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.ResultsThe patients in the early extubation group (n = 53) a...
Source: Neurological Sciences - Category: Neurology Source Type: research
Condition:   Myasthenia Gravis Intervention:   Sponsors:   Charite University, Berlin, Germany;   NeuroCure Clinical Research Center, Charite, Berlin Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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