Clinical relevance of gene expression in localized and metastatic prostate cancer exemplified by FABP5

ConclusionFABP5 overexpression is frequent in PCa, but seems to be restricted toTMPRESS2:ERG fusion-negative tumors and is associated withSPOP andFOXA1 mutations.FABP5 overexpression appears to be indicative for increased activity in PPAR signaling, which is potentially druggable.

Source: World Journal of Urology - January 30, 2019 Category: Urology & Nephrology Source Type: research