Clinical determinants of fitness to drive in persons with multiple sclerosis: systematic review - Krasniuk S, Classen S, Morrow SA, Tippett M, Knott M, Akinwuntan A.
OBJECTIVE: To critically appraise the evidence for the clinical determinants of fitness to drive in adults with Multiple Sclerosis (MS). DATA SOURCES: The research librarian and lead author searched seven databases for driving simulator and on-road studies...
ConclusionData from this large, long-term study indicate that the nature, character, and frequency of SAEs in real-world settings are consistent with natalizumab's known safety profile. (Funded by Biogen; ClinicalTrials.gov identifiers: NCT00477113 and NCT00483847.)
CONCLUSIONS: Our study showed the presence of a structural and functional asymmetry explained by the tendency of increasing the tonus at mRF level in order to compensate the knee stability. We noticed a decrease in Tc value at the mRF level, but close to the value of the two lower limbs. TMG analysis revealed the asymmetry of the muscle composition at the level of the antagonist muscle groups of the thigh, with an increase in the percentage of type II fibers in the previous group, which became hyperton, and a decrease in the percentage of type I fibers in the posterior group. PMID: 31743986 [PubMed - as supplied by publisher]
Publication date: Available online 20 November 2019Source: Neuroscience LettersAuthor(s): Sathiya Sekar, Changiz TaghibiglouAbstractGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been well documented in glycolytic pathway. Independent of this, it has various other functions including stimulator of programmed cell death. Reports suggest that glutamate receptor AMPA type-2 subunit (GluA2) forms protein complex with GAPDH and internalized during excitotoxicity. Further, nuclear accumulation of GluA2 and GAPDH have been studied in neurological disorders like epilepsy and multiple sclerosis, and disruption of this complex...
A Florida-based charity will pay $4 million to resolve claims that it acted as a conduit for companies including Biogen Inc and Novartis AG to pay kickbacks to Medicare patients using their high-priced multiple sclerosis drugs, the U.S. Justice Department said on Wednesday.
Natalizumab (NTZ) is a humanized monoclonal antibody that targets alpha4-integrins reducing leukocytes trafficking across the blood brain barrier . Although NTZ has an unquestionable efficacy on disease activity in relapsing-remitting Multiple Sclerosis (RRMS), its safety profile has been questioned. Progressive multifocal leukoencephalopathy is the most frightening adverse event during NTZ-treatment . However other NTZ-induced side effects have been described, including haematological disorders, particularly frequent in the newborns after NTZ-exposure during pregnancy .
We report a woman with multiple sclerosis who discontinued fingolimod in the first month of her pregnancy. She developed severe disease rebound which responded poorly to steroids. She was started on rituximab, which was continued during the rest of her pregnancy and beyond. Rituximab appeared safe and well tolerated by both mother and infant, and could be considered in pregnancy for those patients with multiple sclerosis who are at high risk of gestational and postpartum relapse.
No abstract available
Condition: Multiple Sclerosis Interventions: Behavioral: Exergames; Behavioral: Adaptive COGNI-TRAcK; Behavioral: Sham COGNI-TRAcK Sponsors: San Camillo Hospital, Rome; Fondazione Don Carlo Gnocchi Onlus; Fondazione Italiana Sclerosi Multipla; Rehabilitation Unit 'Mons. L. Novarese' Hospital, Moncrivello (VC), IT; University of Chieti Not yet recruiting
A strong north-to-south gradient is observed in the distribution of multiple sclerosis (MS), hinting toward an environmental etiology. Vitamin D has been associated with a decreased incidence of MS and may explain, in part, the lower prevalence in tropical climates. However, the existence of MS epidemics implies the possibility of an infectious etiology. Epstein-Barr virus (EBV) infection precedes MS presentation in nearly all affected individuals. While the individual contribution of EBV, vitamin D deficiency, and specific risk genes to MS etiology is possible, their potential interaction is of great interest and may have...
In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MAIT cells were associated with smoking and high concentrations of myelin basic protein in the cerebrospinal fluid. Treatment with alemtuzumab and dimethyl fumarate decreased MAIT cell frequencies.