Differential expression of TGF β1 is associated with fetal regeneration after myocardial infarction.

CONCLUSIONS: TGFβ1 is increased in adult infarcts compared to regenerative, fetal infarcts following MI. While treatment of fetal cardiac fibroblasts with TGFβ1 conveys an adult phenotype, inhibition of TGFβ1 conveys a fetal phenotype to adult cardiac fibroblasts. Decreasing TGFβ1 following MI may facilitate myocardial regeneration by 'fetalizing' the otherwise fibrotic, adult response to MI.
PMID: 30690019 [PubMed - as supplied by publisher]

Source: The Annals of Thoracic Surgery - January 25, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Hodges MM, Zgheib C, Xu J, Hu J, Dewberry LC, Hilton SA, Allukian MW, Gorman JH, Gorman RC, Liechty KW Tags: Ann Thorac Surg Source Type: research