Notch promotes DNMT-mediated hypermethylation of Klotho leads to COPD-related inflammation.

CONCLUSION: Notch-mediated Klotho hypermethylation inhibited Klotho expression, which promoted inflammatory response and cell apoptosis that were associated with the development of COPD.
PMID: 30686068 [PubMed - as supplied by publisher]

Source: Experimental Lung Research - January 30, 2019 Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research