A Prospective, Longitudinal Study of Patient Activity Levels Following Total Knee Arthroplasty Stratified by Demographic and Comorbid Factors
J Knee SurgDOI: 10.1055/s-0034-1388658With the marked increase in the annual number of total knee arthroplasties (TKAs) in the United States, there has been an increased interest in evaluating patient-reported outcomes. The purpose of this study was to prospectively and longitudinally evaluate temporal trends in patient activity levels following TKA and to identify potential demographic and comorbid factors that may affect these outcomes. This prospective study evaluated 281 patients, including 108 men and 173 women, who had a mean age of 66 years (39–80 years) and underwent primary TKA. All patients were followed for a minimum of 2 years. Medical comorbidities were recorded preoperatively and activity scores were evaluated at each follow-up visit. The effects of different patient demographics and systemic comorbidities on activity outcomes were further analyzed using multivariate regression analysis. Compared with preoperative levels, the activity score was observed to initially significantly decrease at 6 weeks postoperatively to below preoperative levels (9.2 vs. 8.1 points). By 3 months, scores were above preoperative levels (10.3 points), but below peak levels. A significant peak in the activity score was observed at 2-year follow-up after which there were no significant differences in scores at 5 years (11.49 vs. 11.47 points). In evaluating patient demographics and comorbidities, significant negative impact of older age, tobacco use, history of cancer, cardiovasc...
Authors: Bilkhu R, Billè A Abstract The coronavirus 2019 (COVID-19) pandemic has caused significant mortality around the world and the focus has been on reducing the number of infections. In order not to compromise treatment of oncology patients, reducing the number of patients with COVID-19 undergoing treatment is mandatory. We reviewed the experience of the National Institute of Cancer in Milan and compared it with our experience. PMID: 32462984 [PubMed - as supplied by publisher]
Conclusion: Adding a BM-TT to FIT-screening considerably reduces colonoscopy burden, but could also decrease screening effectiveness. Combining FIT15 with a high polyp sensitivity BM-TT seems most promising. PMID: 32462913 [PubMed - as supplied by publisher]
This issue of the Surgical Oncology Clinics of North America is devoted to covering the important topic of melanoma. The incidence of primary cutaneous melanoma continues to increase each year. While melanoma accounts for the majority of skin cancer –related deaths, surgical treatment of early disease can be curative. Over the last decade, there have been marked changes in the surgical and systemic treatment of melanoma. For example, within the surgical field, there have been multiple prospective randomized clinical trials to define the exten t of surgery with important changes to how the nodal basin should be managed and staged.
(Nagoya University) Although lymphoma is one of the most common types of blood cancer, it has a rare subtype for which no effective treatment regimens are known. For the first time, Nagoya University researchers and colleagues in Japan have conducted clinical trials for a new treatment protocol and report it to be quite promising.
PMID: 32460969 [PubMed - in process]
This study investigated the impact of gross extrathyroidal extension into major neck structures on the prognosis of papillary thyroid carcinoma according to changes in the American Joint Committee on Cancer (AJCC)/Tumor-Node-Metastasis staging system. Overall, 183 patients with gross extrathyroidal extension into major neck structures were enrolled. The 10-year disease-specific survival (DSS) of patients in each stage showed appropriate correlation and stratification with the AJCC eighth edition. However, the 10-year DSS rate in stage III was better than the expected 10-year DSS rate, according to the AJCC eighth edition. ...
In conclusion, although salvage surgery for structural recurrence of PTC has a high risk of complications, it may be worthwhile when macroscopic curative resection is available. The decision should be made considering various factors including curability, risk of surgical procedure, functional outcome, and life expectancy. PMID: 32461508 [PubMed - as supplied by publisher]
Publication date: Available online 28 May 2020Source: The LancetAuthor(s): Nicole M Kuderer, Toni K Choueiri, Dimpy P Shah, Yu Shyr, Samuel M Rubinstein, Donna R Rivera, Sanjay Shete, Chih-Yuan Hsu, Aakash Desai, Gilberto de Lima Lopes, Petros Grivas, Corrie A Painter, Solange Peters, Michael A Thompson, Ziad Bakouny, Gerald Batist, Tanios Bekaii-Saab, Mehmet A Bilen, Nathaniel Bouganim, Mateo Bover Larroya
Publication date: Available online 28 May 2020Source: The LancetAuthor(s): Lennard Y W Lee, Jean Baptiste Cazier, T Starkey, C D Turnbull, UK Coronavirus Cancer Monitoring Project Team, Rachel Kerr, Gary Middleton
Publication date: Available online 29 May 2020Source: Annals of Medicine and SurgeryAuthor(s): Pushpa Veeralakshmanan, Ji Chung Tham, Amy Wright, Marilyn Bolter, Himanshu Wadhawan, Lee M. Humphreys, Grant Sanders, Tim Wheatley, Richard J. Berrisford, Arun Ariyarathenam