Dipeptidyl peptidase-4 inhibitor linagliptin attenuates neointima formation after vascular injury

In this study, we investigated the vascular-protective effect of the DPP-4 inhibitor, linagliptin, using vascular smooth muscle cells (VSMCs). Methods: Six-week-old male C57BL/6 mice were divided into control (n =19) and linagliptin (3?mg/kg/day, n =20) treated groups. Endothelial denudation injuries were induced in the femoral artery at 8?weeks of age, followed by evaluation of neointima formation at 12?weeks. To evaluate cell proliferation of rat aortic smooth muscle cells, a bromodeoxyuridine (BrdU) incorporation assay was performed. Results: Linagliptin treatment reduced vascular injury-induced neointima formation, compared with controls (p
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research