Pharmacokinetics of Selenium in Healthy Piglets After Different Routes of Administration: Application of Pharmacokinetic Data to the Risk Assessment of Selenium.

Pharmacokinetics of Selenium in Healthy Piglets After Different Routes of Administration: Application of Pharmacokinetic Data to the Risk Assessment of Selenium. Biol Trace Elem Res. 2019 Jan 26;: Authors: Xing H, Zheng S, Zhang Z, Zhu F, Xue H, Xu S Abstract Selenium (Se) is a trace element in the environment. Although it is a necessary trace element for human and animal health, excessive Se can also pollute the environment and show toxic effects on humans and animals. Since the safe dose range of Se is narrow, it is important to study the pharmacokinetics of Se in order to make better use of the biological effects of Se. In the present study, we investigated the pharmacokinetic process of sodium selenate in healthy piglet plasma after either intramuscular injection or oral administrations, and examined dynamic changes of antioxidant system in healthy piglets after Se supplementation. The results showed that the Se reached the peak concentration of (0.2451 ± 0.0123) μg mL-1 at (0.4237 ± 0.0185) h following intramuscular injection administration and (0.1781 ± 0.0142) μg mL-1 at (2.1517 ± 0.1806) h following oral administration in the plasma. The average AUC of sodium selenite following intramuscular injection and oral administrations was (31.7260 ± 1.3574) and (75.1460 ± 3.4127) mg L-1 h-1, respectively. Total antioxidant capacity (T-AOC), glutathione peroxidase (GPx), and superoxide dismutase...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research